P.066 The protective effect of influenza vaccination against stroke in adults

Background: Respiratory infection can be an immediate precursor to stroke and myocardial infarction (MI). Influenza vaccination is associated with reduced risk of MI. This relationship has also been suggested for although it unclear if the effect consistent across age groups. Methods: Using administrative data in Alberta from September 2009 – December 2018 we modelled hazard any individuals recently exposed (< 182 days) influenza vaccine compared those without recent exposure adjusted age, sex, anticoagulant use, atrial fibrillation, COPD, diabetes, hypertension, income quintile, rural/urban home location. Results: 4,141,209 adults (29,687,899 person-years) were included; 1,769,565 (43%) received at least one 10-year time span. 38,126 events recorded. Adjusted demographics comorbidities, significantly (HR: 0.77; 95% CI: 0.76 0.79). persisted all subtypes ages profiles. Conclusions: There a 23% reduction among vaccinated against who not. Protection extended entire adult population was not limited high-risk groups only.